FLIP: a novel regulator of macrophage differentiation and granulocyte homeostasis Running head: FLIP in myeloid cells
نویسندگان
چکیده
Qi-Quan Huang, Harris Perlman, Zan Huang, Robert Birkett, Lixin Kan, Hemant Agrawal, Alexander Misharin, Sandeep Gurbuxani , John D. Crispino, Richard M. Pope Divisions of Rheumatology and Hematology/Oncology, Department of Medicine, Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, IL, 60691, USA; 4 Department of Pathology, University of Chicago. Chicago, IL, 60637 USA
منابع مشابه
PHAGOCYTES, GRANULOCYTES, AND MYELOPOIESIS FLIP: a novel regulator of macrophage differentiation and granulocyte homeostasis
FLIP is a well-established suppressor of death receptor-mediated apoptosis. To define its essential in vivo role in myeloid cells, we generated and characterized mice with Flip conditionally deleted in the myeloid lineage. Myeloid specific Flip-deficient mice exhibited growth retardation, premature death, and splenomegaly with altered architecture and extramedullary hematopoiesis. They also dis...
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FLIP is a well-established suppressor of death receptor-mediated apoptosis. To define its essential in vivo role in myeloid cells, we generated and characterized mice with Flip conditionally deleted in the myeloid lineage. Myeloid specific Flip-deficient mice exhibited growth retardation, premature death, and splenomegaly with altered architecture and extramedullary hematopoiesis. They also dis...
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تاریخ انتشار 2010